Old age is the single greatest risk factor for frailty and diseases ranging from cancer to Alzheimer's. My research contributes to the nascent field of gerotherapeutics, a term used to describe drugs that delay the onset of age-related decline. In particular, I study how small molecules that alter mitochondrial function elicit systemic health benefits. I also have a deep interest in the molecular basis of fitness. By understanding how exercise prevents disease I believe we can make medicines that do the same.
I work with an excellent team of scientists led by Navdeep Chandel at Northwestern University.
My doctoral studies at Yale focused on obesity and type II diabetes.
Here's a link to my CV.
Zachary L. Sebo & Matthew Rodeheffer (2022). Prepubertal androgen signaling is required to establish male fat distibution. Stem Cell Reports.
Zachary L. Sebo & Matthew Rodeheffer (2021). Testosterone metabolites differentially regulate obesogenesis and fat distribution. Molecular Metabolism.
Zachary L. Sebo, Elizabeth Rendina-Ruedy, Gene P. Ables, Dieter M. Lindskog, Matthew S. Rodeheffer, Pouneh K. Fazeli, Mark C. Horowitz (2019). Bone marrow adiposity: basic and clinical implications. Endocrine Reviews.
A full list of publications can be found on PubMed.