I am a postdoctoral fellow in the Chandel Lab at Northwestern University.

The overarching goal of my research is to gain a molecular understanding of human metabolism, with special emphasis on identifying new drug targets. Ongoing work involves extensive mechanism of action studies on metformin and berberine, which are widely used but poorly understood therapeutic molecules that suppress mitochondrial function. I also have a deep interest in the molecular basis of fitness, particularly as it pertains to disease prevention and treatment.

Although exercise is known to provide major health benefits, the underlying mechanisms remain obscure. I am analyzing public omics datasets from human studies to identify candidate drivers of exercise adaptations. Through this work, I aim to inform the development of next-generation therapies for chronic metabolic disorders and other age-related conditions.

Please feel free to contact me with general inquiries or collaboration ideas at zachary.sebo@northwestern.edu.